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發表於 2024-4-12 21:33:34
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本帖最後由 thermostat 於 2024-4-12 21:36 編輯
(https://tetrasod.com/en/oxidative-stress/)
超氧化物歧化酶 (SOD) 被認為是細胞保護免受自由基侵害的關鍵因素，也是防止氧化損傷的第一道防線，也是細胞中最強大的抗氧化劑。 SOD 催化超氧陰離子歧化為過氧化氫(H2O2)，並透過輔助酵素穀胱甘肽過氧化物酶(GPx) 和過氧化氫酶(CAT) 進一步轉化為水(H2O) 和分子氧(O2) 。 鑑於 SOD 的關鍵功能，這些酶可以在所有生物分類群中找到，從原核生物（古細菌和細菌）到低等和高等真核生物，其所擁有的不同酶的數量有所不同。 所有已知的SOD 都是金屬酶，也就是說，它們的活性需要金屬輔助因子，其中鐵(Fe)、鋅(Zn)、鎳(Ni)、銅(Cu) 和錳(Mn) 通常與SOD結合。 TetraSOD® 具有目前自然界中發現的最高 SOD 活性。 根據 Fitoplancton Marino 開發的生產技術，可以測量到高於 30,000 IU/g 乾燥生物質的數字。 對微藻 Tetraselmis chuii 的可用遺傳資訊進行詳細的生物資訊分析，鑑定出編碼 SOD 的三個基因，每個基因都可能對應於 Mn、Cu-Zn 或 Ni 亞型。 這三種酵素的聯合作用使得 TetraSOD® 表現出極高的整體 SOD 活性。
Superoxide dismutases (SOD) are considered key factors in cellular protection against free radicals, representing the first line of defense to prevent oxidative damage, being the most powerful antioxidant in the cell. SOD catalyzes the dismutation of superoxide anion to hydrogen peroxide (H2O2), which is further transformed to water (H2O) and molecular oxygen (O2) by the accessory enzymes glutathione peroxidase (GPx) and catalase (CAT). Given the critical function of SOD, these enzymes can be found in all taxonomic groups of living organisms, from prokaryotes (archaea and bacteria) to lower and higher eukaryotes, differing in the number of different enzymes they possess. All known SOD are metalloenzymes, that is, they require a metal cofactor for the activity, with iron (Fe), zinc (Zn), nickel (Ni), copper (Cu) and manganese (Mn) being those normally bound to SOD. TetraSOD® exhibits the highest SOD activity currently found in nature. Under the production technology developed by Fitoplancton Marino, figures higher than 30,000 IU/g of dried biomass can be measured. A detailed bioinformatic analysis of the available genetic information for the microalgae Tetraselmis chuii has allowed the identification of three genes encoding for SOD, each one potentially corresponding to either Mn, Cu-Zn, or Ni isoforms. The combined action of these three enzymes contributes to the extremely high global SOD activity displayed by TetraSOD®. |
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發表於 2024-4-3 20:13:03
